9/8/2023 0 Comments Clindamycin gel side effectsWhen taken orally, absorption cannot occur until clindamycin palmitate becomes hydrolyzed in the gastrointestinal (GI) tract. Depending on the organism, infection site, and drug concentration, clindamycin may be a bacteriostatic or bactericidal antibiotic. Ĭlindamycin prevents peptide bond formation, thereby inhibiting protein synthesis by reversibly binding to 50S ribosomal subunits. Clindamycin is also a choice for outpatient treatment because of its cost, availability, and effectiveness against methicillin-resistant Staphylococcus aureus. Clindamycin is used in soft tissue infections due to its efficacy against MRSA. Clindamycin is also commonly used in skin and soft tissue infections that are uncomplicated. Īdditionally, clindamycin can be used to treat babesiosis, anthrax, and malaria. It can also be an alternative to metronidazole for treating Gardnerella vaginosis, which presents with gray, fishy vaginal odor with clue cells on wet prep. Gynecologists use clindamycin in combination with gentamycin +/- ampicillin for covering their patients with endometritis. Although not a first-line treatment, The Infectious Diseases Society of America (IDSA) has published guidelines for using intravenous (IV) clindamycin for the inpatient treatment of community-acquired pneumonia and aspiration pneumonia. Dentists will use clindamycin for prophylactic coverage against endocarditis. Anesthesiologists and surgeons will often administer clindamycin per The American Society of Health-System Pharmacists (ASHP) and IDSA guidelines as prophylaxis in the operating room. Clindamycin is also used to treat streptococcal pharyngitis, acne vulgaris, bacterial vaginosis, and severe pelvic inflammatory disease. Clindamycin is FDA-approved to treat septicemia, intra-abdominal infections, lower respiratory infections, gynecological infections, bone, and joint infections, and skin and skin structure infections.
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